Effect of surface grain boundary density on preosteoblast proliferation on titanium

Effect of surface grain boundary density on preosteoblast proliferation on titanium

Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium’s cytocompatibility, discs of UG and...

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Bibliographic Details
Main Authors: Terry C. Lowe, Rebecca A. Reiss, Patrick E. Illescas, Casey F. Davis, Melanie C. Connick, Johnny A. Sena
Format: Article
Language:English
Published: Taylor & Francis Group 2020-06-01
Series:Materials Research Letters
Subjects:
cell proliferation
grain boundary density
ultrafine grain titanium
Online Access:http://dx.doi.org/10.1080/21663831.2020.1744758
Description
Summary:Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium’s cytocompatibility, discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter, the average grain boundary length per surface-attached cell.
ISSN:2166-3831

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