An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog

An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog

Introduction: In the chronic AV-block (CAVB) dog model, structural, contractile, and electrical remodeling occur, which predispose the heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between electrical remodeling and inducibility of TdP, while stru...

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Bibliographic Details
Main Authors: David J. Sprenkeler, Alexandre Bossu, Jet D. M. Beekman, Marieke Schoenmakers, Marc A. Vos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
force-frequency relationship
mechanical restitution
post-extrasystolic potentiation
Torsade de Pointes
contractile remodeling
chronic AV-block dog
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01086/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01086/full

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