Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.

Bibliographic Details
Main Authors: Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07386-5
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spelling doaj-708354e64dcb42588aa6882947904dbf2021-05-11T10:19:14ZengNature Publishing GroupNature Communications2041-17232018-11-019111010.1038/s41467-018-07386-5Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitisPedro H. V. Saavedra0Linyan Huang1Farzaneh Ghazavi2Stephanie Kourula3Tom Vanden Berghe4Nozomi Takahashi5Peter Vandenabeele6Mohamed Lamkanfi7Department of Internal Medicine, Ghent UniversityDepartment of Internal Medicine, Ghent UniversityVIB-UGent Center for Inflammation Research, VIBVIB-UGent Center for Inflammation Research, VIBVIB-UGent Center for Inflammation Research, VIBVIB-UGent Center for Inflammation Research, VIBVIB-UGent Center for Inflammation Research, VIBDepartment of Internal Medicine, Ghent UniversityThe enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.https://doi.org/10.1038/s41467-018-07386-5
collection DOAJ
language English
format Article
sources DOAJ
author Pedro H. V. Saavedra
Linyan Huang
Farzaneh Ghazavi
Stephanie Kourula
Tom Vanden Berghe
Nozomi Takahashi
Peter Vandenabeele
Mohamed Lamkanfi
spellingShingle Pedro H. V. Saavedra
Linyan Huang
Farzaneh Ghazavi
Stephanie Kourula
Tom Vanden Berghe
Nozomi Takahashi
Peter Vandenabeele
Mohamed Lamkanfi
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nature Communications
author_facet Pedro H. V. Saavedra
Linyan Huang
Farzaneh Ghazavi
Stephanie Kourula
Tom Vanden Berghe
Nozomi Takahashi
Peter Vandenabeele
Mohamed Lamkanfi
author_sort Pedro H. V. Saavedra
title Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_short Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_full Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_fullStr Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_full_unstemmed Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
title_sort apoptosis of intestinal epithelial cells restricts clostridium difficile infection in a model of pseudomembranous colitis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.
url https://doi.org/10.1038/s41467-018-07386-5
work_keys_str_mv AT pedrohvsaavedra apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT linyanhuang apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT farzanehghazavi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT stephaniekourula apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT tomvandenberghe apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT nozomitakahashi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT petervandenabeele apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
AT mohamedlamkanfi apoptosisofintestinalepithelialcellsrestrictsclostridiumdifficileinfectioninamodelofpseudomembranouscolitis
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