T Cell Receptor BV Gene Rearrangements in the Spinal Cords and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

T Cell Receptor BV Gene Rearrangements in the Spinal Cords and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal disorder whose etiology and pathogenesis remain unknown. Recent studies, however, have demonstrated the presence of inflammatory infiltrates within ALS spinal cord and suggested the possibility of an immune-mediated process in motor neuron degeneration....

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Bibliographic Details
Main Authors: Michael A. Panzara, Emanuela Gussoni, Ann B. Begovich, Ronald S. Murray, Ying Q. Zang, Stanley H. Appel, Lawrence Steinman, Jingwu Zhang
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neurobiology of Disease
Subjects:
neuromuscular diseases
amyotrophic lateral sclerosis
T-cell antigen receptors
polymerase chain reaction
cellular immunity.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902528

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