Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms

Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms

Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance. Escherichia coli and Pseudomonas aeruginosa are among the most common cause of GN-PJI and ciprofloxacin is the first-line antibiotic. Due t...

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Bibliographic Details
Main Authors: Lei Wang, Mariagrazia Di Luca, Tamta Tkhilaishvili, Andrej Trampuz, Mercedes Gonzalez Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
Escherichia coli
Pseudomonas aeruginosa
biofilm-associated infection
antibiotic activity
synergism
clinical isolates
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02522/full

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