Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells.

Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells.

Benzene is an occupational toxicant and an environmental pollutant that is able to induce the production of reactive oxygen species (ROS), causing oxidative stress and damages of the macromolecules in target cells, such as the hematopoietic stem cells. We had previously found that embryonic yolk sac...

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Bibliographic Details
Main Authors: Jie Zhu, Zhuoyue Bi, Tan Yang, Wei Wang, Zhen Li, Wenting Huang, Liping Wang, Shaozun Zhang, Yanfeng Zhou, Ningna Fan, YuE Bai, Wentao Song, Chunhong Wang, Hong Wang, Yongyi Bi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4250037?pdf=render

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