Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

<p>Abstract</p> <p>Background</p> <p>ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (N...

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Bibliographic Details
Main Authors: Gupta Sandeep, Hammond Charles E, Goldenring James R, Smolka Adam J
Format: Article
Language:English
Published: BMC 2004-02-01
Series:BMC Gastroenterology
Online Access:http://www.biomedcentral.com/1471-230X/4/4