Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan

Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan

Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans. Many drugs and other compounds naturally occurring in our diet (nutraceuticals) have been postulated to a...

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Bibliographic Details
Main Authors: Zoe E. Gillespie, Joshua Pickering, Christopher Eskiw
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Genetics
Subjects:
Aging
Caloric Restriction
Epigenesis, Genetic
Gene Expression
Cancer
caloric restriction mimetics
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00142/full
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spelling doaj-7070e8095a05494fafa609a107cd53012020-11-24T23:15:10ZengFrontiers Media S.A.Frontiers in Genetics1664-80212016-08-01710.3389/fgene.2016.00142196701Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespanZoe E. Gillespie0Joshua Pickering1Christopher Eskiw2Christopher Eskiw3University of SaskatchewanUniversity of SaskatchewanUniversity of SaskatchewanUniversity of SaskatchewanCaloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans. Many drugs and other compounds naturally occurring in our diet (nutraceuticals) have been postulated to act as mimetics of caloric restriction, leading to a wave of research investigating the efficacy of these compounds in preventing age-related diseases and promoting healthier, longer lifespans. Although well studied at the biochemical level, there are still many unanswered questions about how CR and CR mimetics impact genome function and structure. Here we discuss the impact of CR and potential CR mimetics on genome function and structure, including changes in gene expression profiles and epigenetic modifications and their potential to identify the genetic fountain of youth.http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00142/fullAgingCaloric RestrictionEpigenesis, GeneticGene ExpressionCancercaloric restriction mimetics
collection DOAJ
language English
format Article
sources DOAJ
author Zoe E. Gillespie
Joshua Pickering
Christopher Eskiw
Christopher Eskiw
spellingShingle Zoe E. Gillespie
Joshua Pickering
Christopher Eskiw
Christopher Eskiw
Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
Frontiers in Genetics
Aging
Caloric Restriction
Epigenesis, Genetic
Gene Expression
Cancer
caloric restriction mimetics
author_facet Zoe E. Gillespie
Joshua Pickering
Christopher Eskiw
Christopher Eskiw
author_sort Zoe E. Gillespie
title Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
title_short Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
title_full Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
title_fullStr Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
title_full_unstemmed Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
title_sort better living through chemistry: caloric restriction (cr) and cr mimetics alter genome function to promote increased health and lifespan
publisher Frontiers Media S.A.
series Frontiers in Genetics
issn 1664-8021
publishDate 2016-08-01
description Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans. Many drugs and other compounds naturally occurring in our diet (nutraceuticals) have been postulated to act as mimetics of caloric restriction, leading to a wave of research investigating the efficacy of these compounds in preventing age-related diseases and promoting healthier, longer lifespans. Although well studied at the biochemical level, there are still many unanswered questions about how CR and CR mimetics impact genome function and structure. Here we discuss the impact of CR and potential CR mimetics on genome function and structure, including changes in gene expression profiles and epigenetic modifications and their potential to identify the genetic fountain of youth.
topic Aging
Caloric Restriction
Epigenesis, Genetic
Gene Expression
Cancer
caloric restriction mimetics
url http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00142/full
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AT christophereskiw betterlivingthroughchemistrycaloricrestrictioncrandcrmimeticsaltergenomefunctiontopromoteincreasedhealthandlifespan
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