Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics

Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a premutation CGG repeat expansion (55–200 repeats) within the 5′ UTR of the fragile X gene (FMR1). FXTAS is characterized by intension tremor, cerebellar ataxia, progressive neurodegeneration, parkinsonism...

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Bibliographic Details
Main Authors: Ha Eun Kong, Juan Zhao, Shunliang Xu, Peng Jin, Yan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
FXTAS pathogenesis
CGG repeat
RNA toxicity
RAN translation
FXTAS therapeutics
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00128/full

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