PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria

Membrane contact sites between organelles have been shown to play important biological roles. Here, the authors show that at the ER, PDZD8 associates with Protrudin and also with Rab7 endosomes and recruits mitochondria to form three-way contacts.

Bibliographic Details
Main Authors: Yael Elbaz-Alon, Yuting Guo, Nadav Segev, Michal Harel, Daniel E. Quinnell, Tamar Geiger, Ori Avinoam, Dong Li, Jodi Nunnari
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17451-7
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spelling doaj-707039eaf48b40168be3bf1f7653eaa02021-07-25T11:40:05ZengNature Publishing GroupNature Communications2041-17232020-07-0111111410.1038/s41467-020-17451-7PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondriaYael Elbaz-Alon0Yuting Guo1Nadav Segev2Michal Harel3Daniel E. Quinnell4Tamar Geiger5Ori Avinoam6Dong Li7Jodi Nunnari8Department of Molecular and Cellular Biology, University of California DavisNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesDepartment of Biomolecular Sciences, Weizmann Institute of ScienceDepartment of Human Molecular Genetics and Biochemistry, Tel-Aviv UniversityDepartment of Molecular and Cellular Biology, University of California DavisDepartment of Human Molecular Genetics and Biochemistry, Tel-Aviv UniversityDepartment of Biomolecular Sciences, Weizmann Institute of ScienceNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesDepartment of Molecular and Cellular Biology, University of California DavisMembrane contact sites between organelles have been shown to play important biological roles. Here, the authors show that at the ER, PDZD8 associates with Protrudin and also with Rab7 endosomes and recruits mitochondria to form three-way contacts.https://doi.org/10.1038/s41467-020-17451-7
collection DOAJ
language English
format Article
sources DOAJ
author Yael Elbaz-Alon
Yuting Guo
Nadav Segev
Michal Harel
Daniel E. Quinnell
Tamar Geiger
Ori Avinoam
Dong Li
Jodi Nunnari
spellingShingle Yael Elbaz-Alon
Yuting Guo
Nadav Segev
Michal Harel
Daniel E. Quinnell
Tamar Geiger
Ori Avinoam
Dong Li
Jodi Nunnari
PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
Nature Communications
author_facet Yael Elbaz-Alon
Yuting Guo
Nadav Segev
Michal Harel
Daniel E. Quinnell
Tamar Geiger
Ori Avinoam
Dong Li
Jodi Nunnari
author_sort Yael Elbaz-Alon
title PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
title_short PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
title_full PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
title_fullStr PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
title_full_unstemmed PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
title_sort pdzd8 interacts with protrudin and rab7 at er-late endosome membrane contact sites associated with mitochondria
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Membrane contact sites between organelles have been shown to play important biological roles. Here, the authors show that at the ER, PDZD8 associates with Protrudin and also with Rab7 endosomes and recruits mitochondria to form three-way contacts.
url https://doi.org/10.1038/s41467-020-17451-7
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AT jodinunnari pdzd8interactswithprotrudinandrab7aterlateendosomemembranecontactsitesassociatedwithmitochondria
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