A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging is Less Stable in T Cells with Regulatory Capability

A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging is Less Stable in T Cells with Regulatory Capability

Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells. The murine Tg4 T cell receptor recognizes a peptide derived from the self-antigen myelin basic prot...

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Bibliographic Details
Main Authors: Yikui Li, Helen M. Tunbridge, Graham J. Britton, Elaine V. Hill, Parisa Sinai, Silvia Cirillo, Clare Thompson, Farnaz Fallah-Arani, Simon J. Dovedi, David C. Wraith, Christoph Wülfing
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
regulatory T cell
tolerance
immunological synapse
central supramolecular activation cluster (cSMAC), supramolecular signaling complex
linker for activation of T cells (LAT), inhibitory receptors
CTLA-4
Online Access:https://www.mdpi.com/2073-4409/10/2/418

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