Pre-mitotic genome re-organisation bookends the B cell differentiation process

During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs p...

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Main Authors:	Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21536-2

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spelling	doaj-7053b41411834244926ee8cb364e2b612021-03-11T11:33:50ZengNature Publishing GroupNature Communications2041-17232021-02-0112111310.1038/s41467-021-21536-2Pre-mitotic genome re-organisation bookends the B cell differentiation processWing Fuk Chan0Hannah D. Coughlan1Jie H. S. Zhou2Christine R. Keenan3Naiara G. Bediaga4Philip D. Hodgkin5Gordon K. Smyth6Timothy M. Johanson7Rhys S. Allan8The Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchDuring differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.https://doi.org/10.1038/s41467-021-21536-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wing Fuk Chan Hannah D. Coughlan Jie H. S. Zhou Christine R. Keenan Naiara G. Bediaga Philip D. Hodgkin Gordon K. Smyth Timothy M. Johanson Rhys S. Allan
spellingShingle	Wing Fuk Chan Hannah D. Coughlan Jie H. S. Zhou Christine R. Keenan Naiara G. Bediaga Philip D. Hodgkin Gordon K. Smyth Timothy M. Johanson Rhys S. Allan Pre-mitotic genome re-organisation bookends the B cell differentiation process Nature Communications
author_facet	Wing Fuk Chan Hannah D. Coughlan Jie H. S. Zhou Christine R. Keenan Naiara G. Bediaga Philip D. Hodgkin Gordon K. Smyth Timothy M. Johanson Rhys S. Allan
author_sort	Wing Fuk Chan
title	Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_short	Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_full	Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_fullStr	Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_full_unstemmed	Pre-mitotic genome re-organisation bookends the B cell differentiation process
title_sort	pre-mitotic genome re-organisation bookends the b cell differentiation process
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.
url	https://doi.org/10.1038/s41467-021-21536-2
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Pre-mitotic genome re-organisation bookends the B cell differentiation process

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