Pre-mitotic genome re-organisation bookends the B cell differentiation process

Pre-mitotic genome re-organisation bookends the B cell differentiation process

During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs p...

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Bibliographic Details
Main Authors: Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21536-2
Description
Summary:During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.
ISSN:2041-1723

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