Aggressive Natural Killer Cell Leukemia: A Case Report and Literature Update

Aggressive Natural Killer Cell Leukemia: A Case Report and Literature Update

Aggressive natural killer cell leukemia (ANKL) is an extremely rare type of leukemia characterized by clonal NK cell infiltration of peripheral blood and the bone marrow, cytopenias, and hepato/splenomegaly. ANKL is an aggressive subtype of a large granular lymphocytic (LGL) leukemia. Peripheral blo...

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Bibliographic Details
Main Authors: Şamil Ecirli, Orkide Kutlu, Neslihan Andıç, Ceyhan Uğurluoğlu, Abdullah Sakin, Abdülkadir Baştürk
Format: Article
Language:English
Published: Galenos Yayinevi 2015-09-01
Series:İstanbul Medical Journal
Subjects:
NK cell leukemia
aggressive
CD16
CD56
hematopoietic stem cell transplantation
Online Access: http://imj.galenos.com.tr/archives/archive-detail/article-preview/aggressive-natural-killer-cell-leukemia-a-case-rep/20969
Description
Summary:Aggressive natural killer cell leukemia (ANKL) is an extremely rare type of leukemia characterized by clonal NK cell infiltration of peripheral blood and the bone marrow, cytopenias, and hepato/splenomegaly. ANKL is an aggressive subtype of a large granular lymphocytic (LGL) leukemia. Peripheral blood smear shows LGL cells containing characteristic azurophilic granules in a light pale basophilic cytoplasm and immature nuclei. Immunological studies determine CD3-/CD16+/CD56+ and cytoplasmic CD3+. Tumor cells may have EBV positive. Chemotherapy resistance is caused by a multi-drug resistance gene (MDR); thus, patients die within 2 months after diagnosis. Here, we report a rare case of a patient diagnosed with ANKL.
ISSN:2619-9793
2148-094X

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