High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease

High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease

Summary: Nanoparticles promise to advance the field of cardiovascular theranostics. However, their sustained and targeted delivery remains an important obstacle. The body synthesizes some ânaturalâ nanoparticles, including high-density lipoprotein (HDL), which may home to the atherosclerotic plaque...

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Main Authors: Nicholas J. Leeper, MD, Seung-min Park, PhD, Bryan Ronain Smith, PhD
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17300098
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spelling doaj-704d3d11c06c4877817f534d8a5f134c2020-11-24T23:04:54ZengElsevierJACC: Basic to Translational Science2452-302X2017-02-012198100High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular DiseaseNicholas J. Leeper, MD0Seung-min Park, PhD1Bryan Ronain Smith, PhD2Department of Radiology, Stanford University, Stanford, CaliforniaDepartment of Radiology, Stanford University, Stanford, CaliforniaAddress for correspondence: Dr. Bryan Ronain Smith, Department of Radiology, Stanford University, 3155 Porter Drive, Room #1214, Palo Alto, California 94304.; Department of Radiology, Stanford University, Stanford, CaliforniaSummary: Nanoparticles promise to advance the field of cardiovascular theranostics. However, their sustained and targeted delivery remains an important obstacle. The body synthesizes some ânaturalâ nanoparticles, including high-density lipoprotein (HDL), which may home to the atherosclerotic plaque and promote cholesterol efflux. In a recent article published in JACC: Cardiovascular Imaging, investigators generated modified, radiolabeled HDL nanoparticles and confirmed they accumulated in atherosclerotic lesions from several different species. These approaches hold promise for the noninvasive diagnosis of vulnerable plaque and in the stratification of patients in whom HDL-mimetic therapy may have a clinical benefit. Key Words: atherosclerosis, HDL, imaging, nanoparticles, macrophages/monocyteshttp://www.sciencedirect.com/science/article/pii/S2452302X17300098
collection DOAJ
language English
format Article
sources DOAJ
author Nicholas J. Leeper, MD
Seung-min Park, PhD
Bryan Ronain Smith, PhD
spellingShingle Nicholas J. Leeper, MD
Seung-min Park, PhD
Bryan Ronain Smith, PhD
High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
JACC: Basic to Translational Science
author_facet Nicholas J. Leeper, MD
Seung-min Park, PhD
Bryan Ronain Smith, PhD
author_sort Nicholas J. Leeper, MD
title High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
title_short High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
title_full High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
title_fullStr High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
title_full_unstemmed High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease
title_sort high-density lipoprotein nanoparticleâ imaging in atheroscleroticâ vascularâ disease
publisher Elsevier
series JACC: Basic to Translational Science
issn 2452-302X
publishDate 2017-02-01
description Summary: Nanoparticles promise to advance the field of cardiovascular theranostics. However, their sustained and targeted delivery remains an important obstacle. The body synthesizes some ânaturalâ nanoparticles, including high-density lipoprotein (HDL), which may home to the atherosclerotic plaque and promote cholesterol efflux. In a recent article published in JACC: Cardiovascular Imaging, investigators generated modified, radiolabeled HDL nanoparticles and confirmed they accumulated in atherosclerotic lesions from several different species. These approaches hold promise for the noninvasive diagnosis of vulnerable plaque and in the stratification of patients in whom HDL-mimetic therapy may have a clinical benefit. Key Words: atherosclerosis, HDL, imaging, nanoparticles, macrophages/monocytes
url http://www.sciencedirect.com/science/article/pii/S2452302X17300098
work_keys_str_mv AT nicholasjleepermd highdensitylipoproteinnanoparticleaimaginginatheroscleroticavascularadisease
AT seungminparkphd highdensitylipoproteinnanoparticleaimaginginatheroscleroticavascularadisease
AT bryanronainsmithphd highdensitylipoproteinnanoparticleaimaginginatheroscleroticavascularadisease
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