Platelet Activating Factor Synthesis and Metabolism in Intestinal Ischaemia-Reperfusion Injury
The object of this study was to characterize the synthesis and metabolism of platelet activating factor (PAF) by intestinal mucosa subjected to ischaemia–reperfusion injury. Canine intestinal mucosa produced 16:0-PAF, 18:0-PAF, and high levels of the corresponding lyso- PAF metabolites. Three h of i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000554 |
| Summary: | The object of this study was to characterize the synthesis and
metabolism of platelet activating factor (PAF) by intestinal mucosa
subjected to ischaemia–reperfusion injury. Canine intestinal mucosa
produced 16:0-PAF, 18:0-PAF, and high levels of the corresponding
lyso- PAF metabolites. Three h of intestinal ischaemia and ischaemia
followed by 1 h of reperfusion did not affect the synthesis or
metabolism of PAF by intestinal mucosa. Intestinal mucosa elaborated
a factor that rapidly hydrolyzes PAF to lyso-PAF. The observed
hydrolysis rate was not altered by ischaemia or ischaemia and
reperfusion. In conclusion, this study suggests that intestinal
mucosa produces PAF and rapidly hydrolyzes PAF. The PAF synthesis
and metabolism rates of intestinal mucosa is not altered by
ischaemia reperfusion in this model under the imposed conditions. |
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| ISSN: | 0962-9351 1466-1861 |