miR-519d downregulates LEP expression to inhibit preeclampsia development

miR-519d downregulates LEP expression to inhibit preeclampsia development

The purpose of the current study was to characterize role of microRNA (miR)-519d in trophoblast cells and preeclampsia (PE) development and its potential underlying mechanism. Regulation of leptin (LEP) by miR-519d was verified using a dual-luciferase reporter gene assay. Loss- and gain-of-function...

Full description

Bibliographic Details
Main Authors:	Cai Hairui, Li Dongmei, Wu Jun, Shi Chunbo
Format:	Article
Language:	English
Published:	De Gruyter 2021-08-01
Series:	Open Medicine
Subjects:	microrna-519d leptin preeclampsia trophoblast cells
Online Access:	https://doi.org/10.1515/med-2021-0244

Similar Items

miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling
by: Peng Xu, et al.
Published: (2020-12-01)

Aspirin facilitates trophoblast invasion and epithelial-mesenchymal transition by regulating the miR-200-ZEB1 axis in preeclampsia
by: Mei-Tsz Su, et al.
Published: (2021-07-01)

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP
by: Qin Huang, et al.
Published: (2021-02-01)

Pathophysiology of Preeclampsia: The Role of Exosomes
by: Keiichi Matsubara, et al.
Published: (2021-03-01)

Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia
by: Fedorova Larisa, et al.
Published: (2012-02-01)

Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia
by: W. Permadi, et al.
Published: (2020-03-01)

Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models
by: Yi-Wei Han, et al.
Published: (2015-01-01)

Recent Advances of MicroRNAs, Long Non-coding RNAs, and Circular RNAs in Preeclampsia
by: Ailing Chen, et al.
Published: (2021-04-01)

New Insights Into the Role of Placental Aquaporins and the Pathogenesis of Preeclampsia
by: Natalia Szpilbarg, et al.
Published: (2018-10-01)

Cellular characteristics of canine trophoblasts
by: Sahlfeld, Laura
Published: (2012)

Down-Regulation of Neuropathy Target Esterase in Preeclampsia Placenta Inhibits Human Trophoblast Cell Invasion via Modulating MMP-9 Levels
by: Ting Zhong, et al.
Published: (2018-02-01)

HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion
by: Keiichi Matsubara, et al.
Published: (2021-05-01)

Omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its and clinical significance
by: Ping Zhou, et al.
Published: (2018-07-01)

Clinical significance of lncRNA LINC01410 in preeclampsia and its effect on trophoblast proliferation and invasion
by: Hu-Min Gong, et al.
Published: (2021-02-01)

Serum adipocytokines and adiposity as predictive indices of preeclampsia
by: Ahmed Tijani Bawah, et al.
Published: (2020-10-01)

Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia
by: Ayse Kirbas, et al.
Published: (2016-09-01)

THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia
by: Fu-Mei Duan, et al.
Published: (2021-05-01)

MiR-519d and miR-328-3p Combinatorially Suppress Breast Cancer Progression
by: Ma H, et al.
Published: (2020-12-01)

Number of NK cells and expression of its ligands HLA-G and HLA-E in preeclampsia placenta tissue as well as their relationship with cell apoptosis
by: Ya-Li Shi, et al.
Published: (2016-10-01)

AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia
by: Xiaotao Yang, et al.
Published: (2018-08-01)

Disruption in the Regulation of Immune Responses in the Placental Subtype of Preeclampsia
by: Janri Geldenhuys, et al.
Published: (2018-07-01)

Inhibition of TRIM32 Induced by miR-519d Increases the Sensitivity of Colorectal Cancer Cells to Cisplatin
by: Su X, et al.
Published: (2020-01-01)

Decreased Maternal Serum 2-Methoxyestradiol Levels are Associated with the Development of Preeclampsia
by: Zhijun Shen, et al.
Published: (2014-12-01)

lncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis
by: Dan Tang, et al.
Published: (2021-01-01)

Maternal history and uterine artery wave form in the prediction of early-onset and late-onset preeclampsia: A cohort study
by: Nidhi Sharma, et al.
Published: (2018-02-01)

miR-486-5p inhibits invasion and migration of HTR8/SVneo trophoblast cells by down-regulating ARHGAP5
by: Hayashi, M., et al.
Published: (2022)

Comparison of Bcl-xL protein expression in placental trophoblast cells between pregnancy complicated by severe preeclampsia and normotensive pregnancy
by: Diah Rumekti Hadiati, et al.
Published: (2018-03-01)

miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal
by: Ming Liu, et al.
Published: (2018-03-01)

HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction
by: Lauren Anton, et al.
Published: (2019-06-01)

Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling
by: Heyam Hayder, et al.
Published: (2021-04-01)

A novel approach to the differential prognosis of early and late preeclampsia
by: A. N. Strizhakov, et al.
Published: (2018-08-01)

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
by: Jelena Brkić, et al.
Published: (2020-07-01)

New Insights into the Role of Matrix Metalloproteinases in Preeclampsia
by: Salvador Espino Y. Sosa, et al.
Published: (2017-07-01)

STX2 Promotes Trophoblast Growth, Migration, and Invasion Through Activation of the PI3K-AKT Pathway in Preeclampsia
by: Yan Li, et al.
Published: (2021-07-01)

Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases
by: Clara Apicella, et al.
Published: (2021-05-01)

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta
by: Liyan Duan, et al.
Published: (2020-11-01)

The Role of NF-κB in Uterine Spiral Arteries Remodeling, Insight into the Cornerstone of Preeclampsia
by: Maciej W. Socha, et al.
Published: (2021-01-01)

EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression
by: Lanlan Fang, et al.
Published: (2021-10-01)

Preeclampsia-Associated lncRNA INHBA-AS1 Regulates the Proliferation, Invasion, and Migration of Placental Trophoblast Cells
by: Sijia Jiang, et al.
Published: (2020-12-01)

Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR).
by: Hoek, Kim G.P.
Published: (2006)