Genome-Wide DNA Methylation Enhances Stemness in the Mechanical Selection of Tumor-Repopulating Cells

Genome-Wide DNA Methylation Enhances Stemness in the Mechanical Selection of Tumor-Repopulating Cells

BackgroundDNA methylation plays essential roles in tumor occurrence and stemness maintenance. Tumor-repopulating cells (TRCs) are cancer stem cell (CSC)-like cells with highly tumorigenic and self-renewing abilities, which were selected from tumor cells in soft three-dimensional (3D) fibrin gels.Met...

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Bibliographic Details
Main Authors: Wei Huang, Hui Hu, Qiong Zhang, Ning Wang, Xiangliang Yang, An-Yuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
tumor-repopulating cells
DNA methylation
whole-genome bisulfite sequencing
dynamic changes
stemness
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00088/full

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