From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis

From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis

Despite the brilliant bioactive performance of tantalum as an orthopedic biomaterial verified through laboratory researches and clinical practice in the past decades, scarce evidences about the essential mechanisms of how tantalum contributes to osteogenesis were systematically discussed. Up to now,...

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Main Authors: Hu Qian, Ting Lei, Zhimin Ye, Yihe Hu, Pengfei Lei
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/5162524
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spelling doaj-7035070e54c2482b97b951ad616bd9512020-11-25T03:36:41ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/51625245162524From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to OsteogenesisHu Qian0Ting Lei1Zhimin Ye2Yihe Hu3Pengfei Lei4Department of Orthopedics, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Orthopedics, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008, ChinaXiangya School of Medicine, Central South University, 172 Tongzipo Road, Changsha, 410008 Hunan, ChinaDepartment of Orthopedics, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Orthopedics, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008, ChinaDespite the brilliant bioactive performance of tantalum as an orthopedic biomaterial verified through laboratory researches and clinical practice in the past decades, scarce evidences about the essential mechanisms of how tantalum contributes to osteogenesis were systematically discussed. Up to now, a few studies have uncovered preliminarily the biological mechanism of tantalum in osteogenic differentiation and osteogenesis; it is of great necessity to map out the panorama through which tantalum contributes to new bone formation. This minireview summarized current advances to demonstrate the probable signaling pathways and underlying molecular cascades through which tantalum orchestrates osteogenesis, which mainly contain Wnt/β-catenin signaling pathway, BMP signaling pathway, TGF-β signaling pathway, and integrin signaling pathway. Limits of subsistent studies and further work are also discussed, providing a novel vision for the study and application of tantalum.http://dx.doi.org/10.1155/2020/5162524
collection DOAJ
language English
format Article
sources DOAJ
author Hu Qian
Ting Lei
Zhimin Ye
Yihe Hu
Pengfei Lei
spellingShingle Hu Qian
Ting Lei
Zhimin Ye
Yihe Hu
Pengfei Lei
From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
BioMed Research International
author_facet Hu Qian
Ting Lei
Zhimin Ye
Yihe Hu
Pengfei Lei
author_sort Hu Qian
title From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
title_short From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
title_full From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
title_fullStr From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
title_full_unstemmed From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis
title_sort from the performance to the essence: the biological mechanisms of how tantalum contributes to osteogenesis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2020-01-01
description Despite the brilliant bioactive performance of tantalum as an orthopedic biomaterial verified through laboratory researches and clinical practice in the past decades, scarce evidences about the essential mechanisms of how tantalum contributes to osteogenesis were systematically discussed. Up to now, a few studies have uncovered preliminarily the biological mechanism of tantalum in osteogenic differentiation and osteogenesis; it is of great necessity to map out the panorama through which tantalum contributes to new bone formation. This minireview summarized current advances to demonstrate the probable signaling pathways and underlying molecular cascades through which tantalum orchestrates osteogenesis, which mainly contain Wnt/β-catenin signaling pathway, BMP signaling pathway, TGF-β signaling pathway, and integrin signaling pathway. Limits of subsistent studies and further work are also discussed, providing a novel vision for the study and application of tantalum.
url http://dx.doi.org/10.1155/2020/5162524
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