Muscle-type nicotinic receptor blockade by diethylamine, the hydrophilic moiety of lidocaine

Muscle-type nicotinic receptor blockade by diethylamine, the hydrophilic moiety of lidocaine

Lidocaine bears in its structure both an aromatic ring and a terminal amine, which can be protonated at physiological pH, linked by an amide group. Since lidocaine causes multiple inhibitory actions on nicotinic acetylcholine receptors (nAChRs), this work was aimed to determine the inhibitory effect...

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Bibliographic Details
Main Authors:	Armando eAlberola-Die, Gregorio eFernandez-Ballester, José Manuel González-Ros, Isabel eIvorra, Andrés eMorales
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-02-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	Lidocaine nicotinic acetylcholine receptors Xenopus oocytes allosteric modulation Diethylamine microtransplanted receptors
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00012/full

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