Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia

Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia

Microtransplantation (MST), a type of HLA-mismatched allogeneic cellular therapy, is a promising, cellular therapy for acute myeloid leukemia (AML). MST transfuses granulocyte colony-stimulating factor (G-CSF)-mobilized, HLA-mismatched donor peripheral blood stem cells into patients undergoing conve...

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Main Authors: Nathan Punwani, Noah Merin, Ann Mohrbacher, George Yaghmour, Allison Sano, Laleh Ramezani, Preet M. Chaudhary, Giridharan Ramsingh
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048917300481
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spelling doaj-701f21f66efe46c4820a8cf45b1fd1c12020-11-24T21:21:14ZengElsevierLeukemia Research Reports2213-04892018-01-0191820Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemiaNathan Punwani0Noah Merin1Ann Mohrbacher2George Yaghmour3Allison Sano4Laleh Ramezani5Preet M. Chaudhary6Giridharan Ramsingh7Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USABlood and Marrow Transplant Program, Cedar-Sinai Medical Center, Los Angeles, USAJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USAJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USANorris Cancer Hospital, University of Southern California, Los Angeles, USANorris Cancer Hospital, University of Southern California, Los Angeles, USAJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USAJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USA; Corresponding author.Microtransplantation (MST), a type of HLA-mismatched allogeneic cellular therapy, is a promising, cellular therapy for acute myeloid leukemia (AML). MST transfuses granulocyte colony-stimulating factor (G-CSF)-mobilized, HLA-mismatched donor peripheral blood stem cells into patients undergoing conventional chemotherapy. MST, using haploidentical donors, has been shown to yield clinical benefit without any permanent marrow engraftment in AML. Consequently, graft-versus-host disease concerns are rendered irrelevant with no need for immunosuppression. We describe the first reported patient with refractory AML who underwent salvage MST from an unrelated, complete HLA-mismatched donor. The patient achieved remission without complication, warranting further study of unrelated HLA-mismatched donor MST in AML.http://www.sciencedirect.com/science/article/pii/S2213048917300481
collection DOAJ
language English
format Article
sources DOAJ
author Nathan Punwani
Noah Merin
Ann Mohrbacher
George Yaghmour
Allison Sano
Laleh Ramezani
Preet M. Chaudhary
Giridharan Ramsingh
spellingShingle Nathan Punwani
Noah Merin
Ann Mohrbacher
George Yaghmour
Allison Sano
Laleh Ramezani
Preet M. Chaudhary
Giridharan Ramsingh
Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
Leukemia Research Reports
author_facet Nathan Punwani
Noah Merin
Ann Mohrbacher
George Yaghmour
Allison Sano
Laleh Ramezani
Preet M. Chaudhary
Giridharan Ramsingh
author_sort Nathan Punwani
title Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
title_short Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
title_full Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
title_fullStr Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
title_full_unstemmed Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
title_sort unrelated hla mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2018-01-01
description Microtransplantation (MST), a type of HLA-mismatched allogeneic cellular therapy, is a promising, cellular therapy for acute myeloid leukemia (AML). MST transfuses granulocyte colony-stimulating factor (G-CSF)-mobilized, HLA-mismatched donor peripheral blood stem cells into patients undergoing conventional chemotherapy. MST, using haploidentical donors, has been shown to yield clinical benefit without any permanent marrow engraftment in AML. Consequently, graft-versus-host disease concerns are rendered irrelevant with no need for immunosuppression. We describe the first reported patient with refractory AML who underwent salvage MST from an unrelated, complete HLA-mismatched donor. The patient achieved remission without complication, warranting further study of unrelated HLA-mismatched donor MST in AML.
url http://www.sciencedirect.com/science/article/pii/S2213048917300481
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AT preetmchaudhary unrelatedhlamismatchedmicrotransplantationinapatientwithrefractorysecondaryacutemyeloidleukemia
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