Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients

• Main Authors: Biaoxue Rong, Xiling Jiang, Shuanying Yang, Wei Zhang, Xiguang Cai, Jinsui Wang, Min Zhang
• Format: Article
• Language: English
• Published: BMC 2012-08-01
• Series: Journal of Experimental & Clinical Cancer Research
• Subjects: Lung cancer; Hsp90-beta; Annexin A1; Survival; Lymphatic metastasis; Biomarker
• Online Access: http://www.jeccr.com/content/31/1/70

<p>Abstract</p> <p>Background</p> <p>Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.</p> <p>Methods</p> <p>The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, <it>in-situ</it> hybridization, and Western blot.</p> <p>Results</p> <p>Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).</p> <p>Conclusion</p> <p>The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.</p>