Relevance of Regulatory T cell Promotion of Donor-specific Tolerance in Solid Organ Transplantation

Relevance of Regulatory T cell Promotion of Donor-specific Tolerance in Solid Organ Transplantation

Current clinical strategies to control the alloimmune response after transplantation do not fully prevent induction of the immunological processes which lead to acute and chronic immune-mediated graft rejection, and as such the survival of a solid organ allograft is limited. Experimental research on...

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Bibliographic Details
Main Authors: Pervinder eSagoo, Giovanna eLombardi, Robert Ian Lechler
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
Alloantigen
Antigen-specific
direct pathway
Donor-specific
Indirect pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00184/full

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