Perlindungan Hepatotoksisitas Ekstrak Metanol Pegagan Dibanding Vitamin E pada Tikus Model Hepatitis

• Main Authors: Putri Vidyaniati, Armaya Ariyoga, Herri S. Satramihardja
• Format: Article
• Language: English
• Published: Universitas Padjajaran 2011-09-01
• Series: Majalah Kedokteran Bandung
• Subjects: Indian pennywort; liver tissue malondialdehide; necrosis; serum glutamic pyruvic transaminase
• Online Access: http://journal.fk.unpad.ac.id/index.php/mkb/article/view/19

The aim of this study was to evaluate the effect of Indian Pennywort methanol extract on carbontetrachloride (CCl )- 4 induced hepatitis rats model, compared with vitamin E. Parameters used were levels of serum glutamic pyruvic transaminase (SGPT), malondialdehide (MDA), and extent of liver necrosis. Experimental laboratory study was conducted at Pharmacology Laboratory Hasan Sadikin Hospital Bandung, October 2009, with randomized complete design on 40 rats divided into 8 subgroups. The level of SGPT was analyzed by enzymatic method, MDA level was analyzed by Wilbur method. The extent of liver necrosis was analyzed by hematoxylin eosin staining. The results, the extract, if given pre-induction of hepatotoxicity, can significantly prevent the increase of SGPT levels and the extent of necrosis (p ≤0.05), but can't significantly prevent the increase of liver tissue MDA levels (p >0.05). Postinduction, the extract can significantly reduce the SGPT levels, liver tissue MDA levels, and the extent of liver necrosis (p≤0.05). Therefore, effect of the Indian Pennywort extract is better than vitamin E, and can act as hepatoprotector