Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.

Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding drug-metaboli...

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Bibliographic Details
Main Authors: Han-Jin Park, Young-Jun Choi, Ji Woo Kim, Hang-Suk Chun, Ilkyun Im, Seokjoo Yoon, Yong-Mahn Han, Chang-Woo Song, Hyemin Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503736?pdf=render

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http://europepmc.org/articles/PMC4503736?pdf=render

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