Pathogenesis and management strategies of liver failure-associated cholestasis

Liver failure is severe liver injury caused by a variety of factors. Liver failure-associated cholestasis is serious hepatocellular intrahepatic cholestasis with massive hepatocyte necrosis, which manifests as rapid increases in both conjugated and unconjugated bilirubin, and the level of bilirubin...

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Main Author:	MAO Qing
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Hepatology 2019-02-01
Series:	Linchuang Gandanbing Zazhi
Online Access:	http://www.lcgdbzz.org/qk_content.asp?id=9586

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spelling	doaj-6fe78899a35842c5927e7596d71a4af22020-11-25T01:57:57ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562019-02-01352258261Pathogenesis and management strategies of liver failure-associated cholestasisMAO Qing0Department of Infectious Diseases, The First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaLiver failure is severe liver injury caused by a variety of factors. Liver failure-associated cholestasis is serious hepatocellular intrahepatic cholestasis with massive hepatocyte necrosis, which manifests as rapid increases in both conjugated and unconjugated bilirubin, and the level of bilirubin is directly proportional to the severity of liver failure. Structural changes of liver tissue aggravate intrahepatic cholestasis, and intestinal microbiota can affect bilirubin and bile acid metabolism. The management strategies for liver failure-associated cholestasis include eliminating causes, promoting hepatocyte regeneration, and facilitating liver function recovery.http://www.lcgdbzz.org/qk_content.asp?id=9586
collection	DOAJ
language	zho
format	Article
sources	DOAJ
author	MAO Qing
spellingShingle	MAO Qing Pathogenesis and management strategies of liver failure-associated cholestasis Linchuang Gandanbing Zazhi
author_facet	MAO Qing
author_sort	MAO Qing
title	Pathogenesis and management strategies of liver failure-associated cholestasis
title_short	Pathogenesis and management strategies of liver failure-associated cholestasis
title_full	Pathogenesis and management strategies of liver failure-associated cholestasis
title_fullStr	Pathogenesis and management strategies of liver failure-associated cholestasis
title_full_unstemmed	Pathogenesis and management strategies of liver failure-associated cholestasis
title_sort	pathogenesis and management strategies of liver failure-associated cholestasis
publisher	Editorial Department of Journal of Clinical Hepatology
series	Linchuang Gandanbing Zazhi
issn	1001-5256 1001-5256
publishDate	2019-02-01
description	Liver failure is severe liver injury caused by a variety of factors. Liver failure-associated cholestasis is serious hepatocellular intrahepatic cholestasis with massive hepatocyte necrosis, which manifests as rapid increases in both conjugated and unconjugated bilirubin, and the level of bilirubin is directly proportional to the severity of liver failure. Structural changes of liver tissue aggravate intrahepatic cholestasis, and intestinal microbiota can affect bilirubin and bile acid metabolism. The management strategies for liver failure-associated cholestasis include eliminating causes, promoting hepatocyte regeneration, and facilitating liver function recovery.
url	http://www.lcgdbzz.org/qk_content.asp?id=9586
work_keys_str_mv	AT maoqing pathogenesisandmanagementstrategiesofliverfailureassociatedcholestasis
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Pathogenesis and management strategies of liver failure-associated cholestasis

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