Compensatory Thrombopoietin Production from the Liver and Bone Marrow Stimulates Thrombopoiesis of Living Rat Megakaryocytes in Chronic Renal Failure

Compensatory Thrombopoietin Production from the Liver and Bone Marrow Stimulates Thrombopoiesis of Living Rat Megakaryocytes in Chronic Renal Failure

Background/Aims: Decreased thrombopoiesis has been ascribed a role in the pathogenesis of uremic bleeding in chronic renal failure (CRF). However, serum thrombopoietin (TPO) levels are usually elevated in CRF patients, suggesting increased thrombopoiesis. The aim of this study was to determine the t...

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Bibliographic Details
Main Authors: Itsuro Kazama, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Shin Kurosawa, Yoshimichi Murata, Mitsunobu Matsubara, Yoshio Maruyama
Format: Article
Language:English
Published: Karger Publishers 2011-10-01
Series:Nephron Extra
Subjects:
Chronic renal failure
Megakaryocytes
Plasma membrane invaginations
Thrombopoiesis
Thrombopoietin
Uremic bleeding
Online Access:http://www.karger.com/Article/FullText/333018

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