Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases

Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases

Flavoprotein monooxygenases (FPMOs) exhibit an array of mechanistic solutions to a common chemical objective; the monooxygenation of a target substrate. Each FPMO efficiently couples reduction of a flavin cofactor by NAD(P)H to oxygenation of the target substrate via a (hydro)peroxyflavin intermedia...

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Bibliographic Details
Main Authors: Graham R. Moran, Karen Crozier-Reabe
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:International Journal of Molecular Sciences
Subjects:
monooxygenase
flavin
flavoprotein
molecular oxygen
oxygenase
Online Access:http://www.mdpi.com/1422-0067/13/12/15601

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