IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with Sjögren’s syndrome

IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with Sjögren’s syndrome

A small CD3+ T-cell population, that lacks both CD4 and CD8 molecules, defined as double negative (DN), is expanded in the peripheral blood of patients with systemic lupus erythematosus, produces IL-17 and accumulates in the kidney during lupus nephritis. Since IL-17 production is enhanced in saliva...

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Bibliographic Details
Main Authors: A. Alunno, O. Bistoni, E. Bartoloni Bocci, S. Caterbi, B. Bigerna, A. Pucciarini, A. Tabarrini, R. Mannucci, D. Beghelli, B. Falini, R. Gerli
Format: Article
Language:English
Published: PAGEPress Publications 2013-10-01
Series:Reumatismo
Subjects:
T helper 17 cells, Sjögren’s syndrome, dexamethasone.
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/596

Internet

http://www.reumatismo.org/index.php/reuma/article/view/596

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