PEG-Poly(1-Methyl-<span style="font-variant: small-caps">l</span>-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase

PEG-Poly(1-Methyl-<span style="font-variant: small-caps">l</span>-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase

Indoleamine 2,3-dioxygenase (IDO) is an immunomodulating enzyme that is overexpressed in many cancers with poor prognosis. IDO suppresses T cell immunity by catabolizing tryptophan into kynurenine (KYN), which induces apoptosis in T effector cells and enhances T regulatory cells, providing a powerfu...

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Bibliographic Details
Main Authors: George Lo Huang, Anqi Tao, Takuya Miyazaki, Thahomina Khan, Taehun Hong, Yasuhiro Nakagawa, Horacio Cabral
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Nanomaterials
Subjects:
polymeric micelles
indoleamine 2,3-dioxygenase
1-Methyl-Tryptophan
enzymatic degradation
immunotherapy
Online Access:https://www.mdpi.com/2079-4991/9/5/719

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https://www.mdpi.com/2079-4991/9/5/719

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