Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.

Bibliographic Details
Main Authors: Anthony Martin, Gertrude Ecklu-Mensah, Connie W. Y. Ha, Gustaf Hendrick, Donald K. Layman, Jack Gilbert, Suzanne Devkota
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24074-z
Description
Summary:Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.
ISSN:2041-1723

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