Analysis of the correlation between HBV replication markers and HBV markers and liver function in patients with hepatitis B

• Main Authors: Qing-Qing Gu, Dong Wu, Xue-Bing Yan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-06-01
• Series: Journal of Hainan Medical University
• Subjects: Hepatitis B; Viral replication markers; Hepatitis B markers; Liver function; Correlation
• Online Access: http://www.hnykdxxb.com/PDF/201806/04.pdf

Objective: To investigate the correlation between HBV replication markers and HBV markers and liver function in patients with hepatitis B. Methods: A total of 273 cases of chronic hepatitis B patients in our hospital as the hepatitis B group, select 60 healthy people as control group, group monitoring of hepatitis B virus replication index (serum HBV-DNA), HBV serum markers, and monitor the liver function index of the two groups of subjects, analysis of the relationship between serum HBV-DNA level and hepatitis B markers and liver function. Results: HBsAg (+), HBeAg (+), HBcAb (+), the positive rate of HBV-DNA was 100%, HBsAg (+), HBeAb (+), ABcAb (+), the positive rate of HBV-DNA was 47.58%, HBsAg (+), HBeAg (+), HBeAb (+), HBcAb (+) group, the positive rate of HBV-DNA was 69.44%, HBsAg (+), HBcAb (+) group, positive rate of HBV-DNA was 13.64%. The positive rate of HBV-DNA in the greater Sanyang group was significantly higher than that of the other three groups. With the increase of HBV-DNA load, the serum levels of ALT and AST increased significantly, the difference was statistically significant, but there was no significant change in serum CHE level. Conclusion: for hepatitis B patients serum HBV-DNA level in patients with regular monitoring and evaluation of the virus replication, but the HBV-DNA and the degree of liver injury and prognosis of patients with no obvious correlation, also need to pay attention to monitor liver function index of patients, thus accurate assessment and Analysis on the development of the patient's condition.