Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men

Background. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the relations between bilirubin and metabolic syn...

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Main Authors: Xiao-Hong Li, Hai-Yan Lin, Li-Ying Guan, Hui Peng, Meng-Meng Wen, Yong-Qian Cao, Xiu-Yun Jiang, Yi-Bing Wang
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/9621615
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spelling doaj-6fcbd52c3a094ea092725cb38fcbc2502020-11-24T23:02:15ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/96216159621615Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese MenXiao-Hong Li0Hai-Yan Lin1Li-Ying Guan2Hui Peng3Meng-Meng Wen4Yong-Qian Cao5Xiu-Yun Jiang6Yi-Bing Wang7Health Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaHealth Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaHealth Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaHealth Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaHealth Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaDepartment of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaDepartment of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, ChinaBackground. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the relations between bilirubin and metabolic syndrome are inconsistent. Moreover, previous studies mainly focused on serum total bilirubin which is the sum of direct bilirubin and indirect bilirubin. For these reasons, the longitudinal effect of bilirubin subtypes on incident metabolic syndrome was evaluated in Chinese men. Methods. The study cohort involved 1339 Chinese men without metabolic syndrome. Metabolic syndrome was defined by the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, using BMI for the replacement of waist circumference. Results. There are 117 incident metabolic syndrome cases (8.7%) during 5 years of follow-up among 1339 metabolic syndrome-free participants at baseline. After adjusting for age, drinking, smoking, physical activity, TG, and LDL-C, the odd ratios (ORs) and 95% confidence intervals (CIs) for MetS incidence in the second, third, and fourth quartiles versus the first quartile of DBil concentration were 1.00 (0.61–1.63), 0.57 (0.32–1.02), and 0.51 (0.28–0.92) (Ptrend=0.031), respectively. Conclusions. Our findings support the negative association between direct bilirubin and incident metabolic syndrome in healthy Chinese men over 5-year period.http://dx.doi.org/10.1155/2017/9621615
collection DOAJ
language English
format Article
sources DOAJ
author Xiao-Hong Li
Hai-Yan Lin
Li-Ying Guan
Hui Peng
Meng-Meng Wen
Yong-Qian Cao
Xiu-Yun Jiang
Yi-Bing Wang
spellingShingle Xiao-Hong Li
Hai-Yan Lin
Li-Ying Guan
Hui Peng
Meng-Meng Wen
Yong-Qian Cao
Xiu-Yun Jiang
Yi-Bing Wang
Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
BioMed Research International
author_facet Xiao-Hong Li
Hai-Yan Lin
Li-Ying Guan
Hui Peng
Meng-Meng Wen
Yong-Qian Cao
Xiu-Yun Jiang
Yi-Bing Wang
author_sort Xiao-Hong Li
title Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
title_short Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
title_full Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
title_fullStr Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
title_full_unstemmed Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men
title_sort direct bilirubin levels and risk of metabolic syndrome in healthy chinese men
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Background. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the relations between bilirubin and metabolic syndrome are inconsistent. Moreover, previous studies mainly focused on serum total bilirubin which is the sum of direct bilirubin and indirect bilirubin. For these reasons, the longitudinal effect of bilirubin subtypes on incident metabolic syndrome was evaluated in Chinese men. Methods. The study cohort involved 1339 Chinese men without metabolic syndrome. Metabolic syndrome was defined by the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, using BMI for the replacement of waist circumference. Results. There are 117 incident metabolic syndrome cases (8.7%) during 5 years of follow-up among 1339 metabolic syndrome-free participants at baseline. After adjusting for age, drinking, smoking, physical activity, TG, and LDL-C, the odd ratios (ORs) and 95% confidence intervals (CIs) for MetS incidence in the second, third, and fourth quartiles versus the first quartile of DBil concentration were 1.00 (0.61–1.63), 0.57 (0.32–1.02), and 0.51 (0.28–0.92) (Ptrend=0.031), respectively. Conclusions. Our findings support the negative association between direct bilirubin and incident metabolic syndrome in healthy Chinese men over 5-year period.
url http://dx.doi.org/10.1155/2017/9621615
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