SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast

SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast

Chromatin structure clearly modulates gene expression noise, but the reverse influence has never been investigated, namely how the cell-to-cell expression heterogeneity of chromatin modifiers may generate variable rates of epigenetic modification. Sir2 is a well-characterized histone deacetylase of...

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Bibliographic Details
Main Authors: Jian Liu, Laureline Mosser, Catherine Botanch, Jean-Marie François, Jean-Pascal Capp
Format: Article
Language:English
Published: Oxford University Press 2020-09-01
Series:G3: Genes, Genomes, Genetics
Subjects:
epigenetics
sir2
silencing
gene expression noise
viability
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401589

Internet

http://g3journal.org/lookup/doi/10.1534/g3.120.401589

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