Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

Abstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of ca...

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Main Authors: Farnaz Rasi-Bonab, Abolfazl Jafari-Sales, Mohammad Amin Shaverdi, Tahereh Navidifar, Morteza Saki, Atosa Ghorbani, Abimbola Olumide Adekanmbi, Behboud Jafari, Sara Naebi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Research Notes
Subjects:
Antibiotic resistance
cagA
Clarithromycin
Helicobacter pylori
Iran
Metronidazole
Online Access:https://doi.org/10.1186/s13104-021-05633-5
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spelling doaj-6fc4fb619c7a4f389c15e891a7fa9a082021-06-06T11:44:50ZengBMCBMC Research Notes1756-05002021-05-011411510.1186/s13104-021-05633-5Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, IranFarnaz Rasi-Bonab0Abolfazl Jafari-Sales1Mohammad Amin Shaverdi2Tahereh Navidifar3Morteza Saki4Atosa Ghorbani5Abimbola Olumide Adekanmbi6Behboud Jafari7Sara Naebi8Department of Microbiology, Marand Branch, Islamic Azad UniversityDepartment of Microbiology, School of Basic Sciences, Kazerun Branch, Islamic Azad UniversityBlood Transfusion Research Center, High Institute for Research and Education in Transfusion MedicineShoushtar Faculty of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesEnvironmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of IbadanDepartment of Microbiology, Ahar Branch, Islamic Azad UniversityDepartment of Microbiology, Ahar Branch, Islamic Azad UniversityAbstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. Results The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).https://doi.org/10.1186/s13104-021-05633-5Antibiotic resistancecagAClarithromycinHelicobacter pyloriIranMetronidazole
collection DOAJ
language English
format Article
sources DOAJ
author Farnaz Rasi-Bonab
Abolfazl Jafari-Sales
Mohammad Amin Shaverdi
Tahereh Navidifar
Morteza Saki
Atosa Ghorbani
Abimbola Olumide Adekanmbi
Behboud Jafari
Sara Naebi
spellingShingle Farnaz Rasi-Bonab
Abolfazl Jafari-Sales
Mohammad Amin Shaverdi
Tahereh Navidifar
Morteza Saki
Atosa Ghorbani
Abimbola Olumide Adekanmbi
Behboud Jafari
Sara Naebi
Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
BMC Research Notes
Antibiotic resistance
cagA
Clarithromycin
Helicobacter pylori
Iran
Metronidazole
author_facet Farnaz Rasi-Bonab
Abolfazl Jafari-Sales
Mohammad Amin Shaverdi
Tahereh Navidifar
Morteza Saki
Atosa Ghorbani
Abimbola Olumide Adekanmbi
Behboud Jafari
Sara Naebi
author_sort Farnaz Rasi-Bonab
title Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_short Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_full Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_fullStr Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_full_unstemmed Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_sort antibiotic resistance pattern and frequency of caga and vaca genes in helicobacter pylori strains isolated from patients in tabriz city, iran
publisher BMC
series BMC Research Notes
issn 1756-0500
publishDate 2021-05-01
description Abstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. Results The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
topic Antibiotic resistance
cagA
Clarithromycin
Helicobacter pylori
Iran
Metronidazole
url https://doi.org/10.1186/s13104-021-05633-5
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