Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

Abstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of ca...

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Bibliographic Details
Main Authors: Farnaz Rasi-Bonab, Abolfazl Jafari-Sales, Mohammad Amin Shaverdi, Tahereh Navidifar, Morteza Saki, Atosa Ghorbani, Abimbola Olumide Adekanmbi, Behboud Jafari, Sara Naebi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Research Notes
Subjects:
Antibiotic resistance
cagA
Clarithromycin
Helicobacter pylori
Iran
Metronidazole
Online Access:https://doi.org/10.1186/s13104-021-05633-5
Description
Summary:Abstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. Results The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
ISSN:1756-0500

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