Identification of small-molecule ion channel modulators in C. elegans channelopathy models
Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06514-5 |