Identification of small-molecule ion channel modulators in C. elegans channelopathy models

Identification of small-molecule ion channel modulators in C. elegans channelopathy models

Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.

Bibliographic Details
Main Authors: Qiang Jiang, Kai Li, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan, Shi-Qing Cai
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06514-5
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spelling doaj-6fbe7f0d2c174c07a41338abdebd0bc42021-05-11T09:30:02ZengNature Publishing GroupNature Communications2041-17232018-09-019111210.1038/s41467-018-06514-5Identification of small-molecule ion channel modulators in C. elegans channelopathy modelsQiang Jiang0Kai Li1Wen-Jing Lu2Shuang Li3Xin Chen4Xi-Juan Liu5Jie Yuan6Qiurong Ding7Feng Lan8Shi-Qing Cai9Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesBeijing Laboratory for Cardiovascular Precision Medicine, Beijing Anzhen Hospital, Capital Medical UniversityUniversity of Chinese Academy of SciencesInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesBeijing Laboratory for Cardiovascular Precision Medicine, Beijing Anzhen Hospital, Capital Medical UniversityInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesMutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.https://doi.org/10.1038/s41467-018-06514-5
collection DOAJ
language English
format Article
sources DOAJ
author Qiang Jiang
Kai Li
Wen-Jing Lu
Shuang Li
Xin Chen
Xi-Juan Liu
Jie Yuan
Qiurong Ding
Feng Lan
Shi-Qing Cai
spellingShingle Qiang Jiang
Kai Li
Wen-Jing Lu
Shuang Li
Xin Chen
Xi-Juan Liu
Jie Yuan
Qiurong Ding
Feng Lan
Shi-Qing Cai
Identification of small-molecule ion channel modulators in C. elegans channelopathy models
Nature Communications
author_facet Qiang Jiang
Kai Li
Wen-Jing Lu
Shuang Li
Xin Chen
Xi-Juan Liu
Jie Yuan
Qiurong Ding
Feng Lan
Shi-Qing Cai
author_sort Qiang Jiang
title Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_short Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_full Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_fullStr Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_full_unstemmed Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_sort identification of small-molecule ion channel modulators in c. elegans channelopathy models
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.
url https://doi.org/10.1038/s41467-018-06514-5
work_keys_str_mv AT qiangjiang identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
AT kaili identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
AT wenjinglu identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
AT shuangli identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
AT xinchen identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
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AT qiurongding identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
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