Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.

Bibliographic Details
Main Authors:	Li-Wei Tung, Guan-Ling Lu, Yen-Hsien Lee, Lung Yu, Hsin-Jung Lee, Emma Leishman, Heather Bradshaw, Ling-Ling Hwang, Ming-Shiu Hung, Ken Mackie, Andreas Zimmer, Lih-Chu Chiou
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12199

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spelling	doaj-6fb8a2e8693f4fcf8b5d51e6da9be8c12021-05-11T11:09:19ZengNature Publishing GroupNature Communications2041-17232016-07-017111410.1038/ncomms12199Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neuronsLi-Wei Tung0Guan-Ling Lu1Yen-Hsien Lee2Lung Yu3Hsin-Jung Lee4Emma Leishman5Heather Bradshaw6Ling-Ling Hwang7Ming-Shiu Hung8Ken Mackie9Andreas Zimmer10Lih-Chu Chiou11Graduate Institute of Pharmacology, College of Medicine, National Taiwan UniversityGraduate Institute of Pharmacology, College of Medicine, National Taiwan UniversityGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical UniversityInstitute of Behavioral Medicine, College of Medicine, National Cheng Kung UniversityDepartment of Pharmacology, College of Medicine, National Taiwan UniversityGill Center and the Department of Psychological and Brain Sciences, Indiana UniversityGill Center and the Department of Psychological and Brain Sciences, Indiana UniversityGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical UniversityInstitute of Biotechnology and Pharmaceutical Research, National Health Research InstitutesGill Center and the Department of Psychological and Brain Sciences, Indiana UniversityInstitute for Molecular Psychiatry, Medical Faculty, University of BonnGraduate Institute of Pharmacology, College of Medicine, National Taiwan UniversityStress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.https://doi.org/10.1038/ncomms12199
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou
spellingShingle	Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons Nature Communications
author_facet	Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou
author_sort	Li-Wei Tung
title	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_short	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_full	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_fullStr	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_full_unstemmed	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_sort	orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-07-01
description	Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.
url	https://doi.org/10.1038/ncomms12199
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Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

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