Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.
Bibliographic Details
| Main Authors: |
Li-Wei Tung,
Guan-Ling Lu,
Yen-Hsien Lee,
Lung Yu,
Hsin-Jung Lee,
Emma Leishman,
Heather Bradshaw,
Ling-Ling Hwang,
Ming-Shiu Hung,
Ken Mackie,
Andreas Zimmer,
Lih-Chu Chiou |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12199
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