Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes (2DM) and develop largely in response to common key modulators such oxidative stress (OS), inflammation and alterations o...

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Bibliographic Details
Main Authors: Mohammad A. Kaisar, Heidi Villalba, Shikha Prasad, Taylor Liles, Ali Ehsan Sifat, Ravi K. Sajja, Thomas J. Abbruscato, Luca Cucullo
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
Oxidative stress
Cigarette smoke
Vaping
Metformin
Ischemia, Blood Hemostasis
Blood-brain barrier
Inflammation
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717304433

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http://www.sciencedirect.com/science/article/pii/S2213231717304433

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