Study of Association of Serum Uric Acid with Serum Lipids, Left Ventricular Ejection Fraction and In-hospital Outcome in Patients with Acute ST-Elevation Myocardial Infarction: An Observational Study

• Main Authors: Ravindra Pal, Prabhat Kanvaria, C L Nawal
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-01-01
• Series: Advances in Human Biology
• Subjects: Left ventricular ejection fraction; serum lipids; serum uric acid
• Online Access: http://www.aihbonline.com/article.asp?issn=2321-8568;year=2016;volume=6;issue=3;spage=132;epage=135;aulast=Pal
• ISSN: 2321-8568; 2348-4691

Aim: The aim of this study was to assess the clinical value of serum uric acid (SUA) levels in patients with acute ST-elevation myocardial infarction (STEMI). Materials and Methods: Totally 200 consecutive patients with STEMI were prospectively studied from January 2014 to December 2014. The levels of serum lipid, left ventricular ejection fraction (LVEF) and in-hospital major adverse cardiovascular events in patients with hyperuricaemia (n = 56) were compared with those in patients without hyperuricaemia (n = 144). All data were analysed with GraphPad prism version 6.0 software (Graphpad Software, Inc., CA, USA). Results: SUA level was positively correlated with serum triglyceride level (TGL) (r = 0.102, P = 0.042) and negatively with high-density lipoprotein-cholesterol (HDL-C) (r = −0.149, P = 0.0034). Serum TGL was significantly higher in hyperuricaemic patients (153.7 ΁ 63.87 vs. 138.2 ΁ 34.69, P = 0.027). Patients with left ventricular failure (P = 0.006) and cardiogenic shock (P = 0.029) had significantly higher levels of uric acid. There was no significant difference in males and females with respect to serum TGLs, cardiogenic shock and left ventricular failure. However, no significant association was observed between SUA level and diabetes mellitus, hypertension, LVEF, HDL-C, low-density lipoprotein-cholesterol, total cholesterol, acute renal failure and overall mortality. Conclusion: We conclude that high SUA is significantly associated with high serum TGLs and occurrence of cardiogenic shock and left ventricular failure irrespective of the sex.