Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

Therapeutic targeting of estrogen receptor-α (ERα) by the anti-estrogen tamoxifen is standard of care for premenopausal breast cancer patients and remains a key component of treatment strategies for postmenopausal patients. While tamoxifen significantly increases overall survival...

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Bibliographic Details
Main Authors: Nicholas Pulliam, Jessica Tang, Weini Wang, Fang Fang, Riddhi Sood, Heather M. O’Hagan, Kathy D. Miller, Robert Clarke, Kenneth P. Nephew
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
breast cancer
estrogen receptor
tamoxifen
antiestrogen resistance
PARP inhibitor
Online Access:http://www.mdpi.com/2072-6694/11/1/43

Internet

http://www.mdpi.com/2072-6694/11/1/43

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