Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?

Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 year...

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Main Authors: S Radha, T Afroz, Ch R Prasad, G Sridhar, K G Rajaram, S Reddy
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Indian Journal of Nephrology
Subjects:
Online Access:http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=82;epage=85;aulast=Radha
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spelling doaj-6fa2c608b7974db2a1a1bc10225342282020-11-25T01:36:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Nephrology0971-40651998-36622015-01-01252828510.4103/0971-4065.137173Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?S RadhaT AfrozCh R PrasadG SridharK G RajaramS ReddyRecurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=82;epage=85;aulast=RadhaFocal segmental glomerulosclerosisrenal allograftskidney transplantation
collection DOAJ
language English
format Article
sources DOAJ
author S Radha
T Afroz
Ch R Prasad
G Sridhar
K G Rajaram
S Reddy
spellingShingle S Radha
T Afroz
Ch R Prasad
G Sridhar
K G Rajaram
S Reddy
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
Indian Journal of Nephrology
Focal segmental glomerulosclerosis
renal allografts
kidney transplantation
author_facet S Radha
T Afroz
Ch R Prasad
G Sridhar
K G Rajaram
S Reddy
author_sort S Radha
title Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
title_short Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
title_full Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
title_fullStr Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
title_full_unstemmed Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
title_sort focal segmental glomerulosclerosis in renal allografts: is it possible to diagnose the etiology?
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Nephrology
issn 0971-4065
1998-3662
publishDate 2015-01-01
description Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.
topic Focal segmental glomerulosclerosis
renal allografts
kidney transplantation
url http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=82;epage=85;aulast=Radha
work_keys_str_mv AT sradha focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
AT tafroz focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
AT chrprasad focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
AT gsridhar focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
AT kgrajaram focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
AT sreddy focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology
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