Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 year...
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2015-01-01
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doaj-6fa2c608b7974db2a1a1bc10225342282020-11-25T01:36:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Nephrology0971-40651998-36622015-01-01252828510.4103/0971-4065.137173Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?S RadhaT AfrozCh R PrasadG SridharK G RajaramS ReddyRecurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=82;epage=85;aulast=RadhaFocal segmental glomerulosclerosisrenal allograftskidney transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S Radha T Afroz Ch R Prasad G Sridhar K G Rajaram S Reddy |
spellingShingle |
S Radha T Afroz Ch R Prasad G Sridhar K G Rajaram S Reddy Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? Indian Journal of Nephrology Focal segmental glomerulosclerosis renal allografts kidney transplantation |
author_facet |
S Radha T Afroz Ch R Prasad G Sridhar K G Rajaram S Reddy |
author_sort |
S Radha |
title |
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? |
title_short |
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? |
title_full |
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? |
title_fullStr |
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? |
title_full_unstemmed |
Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? |
title_sort |
focal segmental glomerulosclerosis in renal allografts: is it possible to diagnose the etiology? |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Nephrology |
issn |
0971-4065 1998-3662 |
publishDate |
2015-01-01 |
description |
Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases. |
topic |
Focal segmental glomerulosclerosis renal allografts kidney transplantation |
url |
http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=82;epage=85;aulast=Radha |
work_keys_str_mv |
AT sradha focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology AT tafroz focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology AT chrprasad focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology AT gsridhar focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology AT kgrajaram focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology AT sreddy focalsegmentalglomerulosclerosisinrenalallograftsisitpossibletodiagnosetheetiology |
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