Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2

Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2

The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation. Protein levels of p53 and its transcriptional activity are tightly regulated by the ubiquitin E3 ligase MDM2, the gene expression of which is transcriptionally re...

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Bibliographic Details
Main Authors: Jesús García‐Cano, Susana Sánchez‐Tena, Joan Sala‐Gaston, Agnès Figueras, Francesc Viñals, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Molecular Oncology
Subjects:
DNA damage
HERC2
MDM2
NEURL4
p53
tumor suppressor
Online Access:https://doi.org/10.1002/1878-0261.12592

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