Acute Administration of MK-801 in an Animal Model of Psychosis in Rats Interferes with Cognitively Demanding Forms of Behavioral Flexibility on a Rotating Arena

Acute Administration of MK-801 in an Animal Model of Psychosis in Rats Interferes with Cognitively Demanding Forms of Behavioral Flexibility on a Rotating Arena

Patients with schizophrenia often manifest deficits in behavioral flexibility. Non-competitive NMDA receptor antagonists such as MK-801 induce schizophrenia-like symptoms in rodents, including cognitive functions. Despite work exploring flexibility has been done employing behavioral paradigms with s...

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Bibliographic Details
Main Authors: Jan eSvoboda, Anna eStankova, Marie eEntlerova, Ales eStuchlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Schizophrenia
rat
cognitive flexibility
MK-801
set-shifting
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Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00075/full

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