The Specific Activity of 18F-Fallypride Effect on Dopamine D2 Receptor Imaging

• Main Author: MU Chang-ping1;LI Kang1;ZHOU Shao-quan1;WANG Yan2;TANG Ling-ling2;ZHANG Zhen-zhen2;YANG Min3
• Format: Article
• Language: zho
• Published: Editorial Board of Journal of Isotopes 2016-10-01
• Series: Journal of Isotopes
• Online Access: http://www.tws.org.cn/CN/10.7538/tws.2016.29.02.0071

To study the specific activity requirement of 18F-Fallypride for dopamine D2 receptor PET imaging, 18F-Fallypride was prepared by nucleophilic reaction and purified by HPLC. The specific activity was measured. Different concentrations of 19F-Fallypride and 18F-Fallypride (3.7 MBq) were mixed to simulate the specific activity. After the mixture was intravenous injected into normal mice 10 min, Micro PET was carried out, and then the uptake of 18F-Fallypride in striatum was analyzed. The striatum uptake of 18F-Fallypride decreased when the specific activity decreased, and the uptake value with the log concentration of 19F-Fallypride exhibited S-shaped curve. Based on these, 18F-Fallypride can be used for striatum Micro PET imaging with the specific activity no less than 1.35 PBq/mol. The specific activity is an important factor in the 18F-Fallypride dopamine D2 receptor imaging.