RNA-Seq data on prefrontal cortex in valproic acid model of autism and control rats

• Main Authors: Zhaoqiang Qian, Ruoxin Zhang, Jinlong Zhou, Siqi Sun, Yuanyuan Di, Wei Ren, Yingfang Tian
• Format: Article
• Language: English
• Published: Elsevier 2018-06-01
• Series: Data in Brief
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352340918302889

The transcriptome sequencing data of valproic acid (VPA) model of autism and control rats are presented. VPA model of autism was induced by a single intraperitoneal injection of 600 mg/kg sodium valproic acid to female rats at day 12.5 post-conception, and the control rats were injected with saline. Male offspring of VPA- or saline-injected dams from different litters were sacrificed on PND 35 (n = three rats/three litters/group). Prefrontal cortex was dissected from both hemispheres, and RNA was isolated. Libraries were prepared and RNA Sequencing (RNA-Seq) was performed following Illumina's recommendations. Samples are described in the SRA portal (SRP115258) and FASTQ files have been deposited in Sequence Read Archive (accession numbers: SRR5950172 to SRR5950177). The interpretation of these data is presented in the following research article: “Transcriptional and splicing dysregulation in prefrontal cortex of valproic acid induced rat models of autism” (Zhang et al., 2018) [1].