Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression

Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression

Abstract Background Knee osteoarthritis (KOA) is a common cause of disability among the elderly. We aimed to explore the effects of aldehyde dehydrogenase (ALDH) 2 on the progression of KOA and identifying the potential mechanisms. Methods First, ALDH2 expression in knee joint effusion of patients w...

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Bibliographic Details
Main Authors: Lingxiao Pan, Wei Ding, Jie Li, Kaifeng Gan, Yandong Shen, Junxiang Xu, Minzhe Zheng
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BioMedical Engineering OnLine
Subjects:
Knee osteoarthritis
ALDH
Oxidative stress
Inflammation
Apoptosis
AQP4
Online Access:https://doi.org/10.1186/s12938-021-00917-0

Internet

https://doi.org/10.1186/s12938-021-00917-0

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