Molecular Dynamics Simulations of Influenza a Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets

Molecular Dynamics Simulations of Influenza a Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets

The non-structural protein NS1 of influenza A viruses is considered to be the major antagonist of the interferon system and antiviral defenses of the cell. It could therefore represent a suitable target for novel antiviral strategies. As a first step towards the identification of small compounds tar...

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Bibliographic Details
Main Authors: Hiba Abi Hussein, Colette Geneix, Camille Cauvin, Daniel Marc, Delphine Flatters, Anne-Claude Camproux
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
influenza A virus
NS1
molecular dynamics
druggability
druggable pockets
Online Access:https://www.mdpi.com/1999-4915/12/5/537

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